临床场景Clinical Context

病理说“这里切缘阳性”,创面上究竟是哪一点?A margin is positive. Which point on the wound does it correspond to?

头颈肿瘤切除后,标本进入病理流程,患者的创面则留在手术台上。如果病理发现某处切缘阳性,医生需要把标本上的这个位置准确找回到创面,决定从哪里追加切除。问题在于,标本离体后会旋转、收缩和变形,它已无法像一块拼图一样直接放回原位。After a head and neck tumor is removed, the specimen enters the pathology workflow while the wound remains on the operating table. If a margin is positive, the surgeon must find its counterpart on the wound and decide where to re-resect. Rotation, shrinkage, and deformation mean the specimen no longer fits back like an unchanged puzzle piece.

“靠近上缘”或“某个方向的一角”这样的口头描述,仍需要医生结合记忆、解剖特征和标本方向进行判断。头颈区域的神经、血管和重要外观结构相邻,追加切除既要对准可疑位置,也要谨慎保留周围组织。A verbal description such as “near the upper edge” still depends on the surgeon’s memory of anatomy and specimen orientation. In the head and neck, nerves, vessels, and structures important to appearance sit close together, so additional resection must target the suspected site while carefully preserving surrounding tissue.

系统保留三维标本及其切缘标注,通过轮廓约束形变和创面配准,将目标映射回患者一侧,并锚定在 AR 视野中。病理负责判断切缘,导航负责把这一判断所对应的空间位置传递回医生眼前。The system preserves a 3D specimen with margin annotations, then uses contour-constrained deformation and wound-bed registration to map targets back to the patient and anchor them in AR. Pathology determines margin status; navigation communicates the corresponding spatial location back to the surgeon.

  1. 01

    标本上发现阳性切缘Positive margin on the specimen

    病理提供位置标注Pathology provides the annotation

  2. 02

    离体后难以对位Difficult relocation after excision

    旋转、收缩改变对应关系Rotation and shrinkage change the mapping

  3. 03

    创面上显示目标Target displayed on the wound

    形变映射后原位标示Deform and map the annotation in situ

定位挑战与导航思路示意Schematic of the localization challenge and navigation approach
工作流程Workflow

从采集到术野显示From acquisition to in-field display

01

三维标本与切缘标注3D specimen and margin labels

扫描切除标本,在病理流程中记录需要再次定位的切缘位置。Scan the resected specimen and annotate margin locations identified through the pathology workflow.

02

轮廓约束形变Contour-constrained deformation

结合珠状缝线对应点与创面轮廓,使用 Kelvinlet 模型补偿离体形变。Bead-suture correspondences and wound contours constrain a Kelvinlet model of specimen deformation.

03

无标记 AR 融合Marker-free AR fusion

将形变标本配准到创面点云,并在铺巾条件下完成创面与头显坐标对齐。Register the deformed specimen to the bed point cloud, then align the bed with the headset while accounting for drapes.

04

再切除目标显示Re-resection target display

将标注锚定在创面对应位置,帮助医生定位拟再次切除的区域。Anchor margin labels to the corresponding wound-bed locations to guide target relocation.

“无标记”指患者与头显之间的 AR 融合无需外部标志物;标本形变建模仍使用珠状缝线对应点,病理判断仍由病理流程提供。Marker-free refers to patient-to-headset AR fusion. Specimen deformation still uses bead-suture correspondences, and margin assessment remains part of the pathology workflow.

研究进展Research Progress

系统特点与验证边界System characteristics and validation scope

6.19 ± 1.79 mm

AR 引导端到端定位误差End-to-end localization error with AR

21.40 ± 3.84 mm

口头引导对照误差Error with verbal guidance

5.23 ± 0.34 s

在线融合时间Online fusion time

研究在面颊与头皮两个尸体模型部位开展,包含 5 位外科住院医师及专科培训医师。口头引导加标本查看组的定位误差为 16.09 ± 4.30 mm。结果支持可行性,尚不代表临床疗效;在线融合时间不包含标本扫描等准备步骤,原型的附加手动步骤约需 10 分钟。The study included cheek and scalp cadaveric sites and five surgical residents and fellows. Verbal guidance with specimen examination yielded 16.09 ± 4.30 mm localization error. Results support feasibility, not clinical efficacy. Online fusion time excludes specimen scanning and other preparation; added manual steps took approximately 10 minutes in the prototype.

研究依据 · 稿件Research basis · manuscript

Marker-free deformable registration and fusion for augmented reality-guided positive margin localization during tumor re-resection surgery

Yue Yang, Annie Benson, Matthieu Chabanas, Jason Slagle, Thomas Myles, Matthew Weinger, Jon Heiselman, Michael Miga, Michael Topf, Jie Ying Wu

一起推进术中空间导航Advance spatial navigation together

欢迎联系,了解系统演示与研究合作。Contact us for system demonstrations and research collaboration.