形变计算Deformation modeling

LIBR:让模型回应组织的形变LIBR: modeling tissue as it changes shape

术前扫描与术中组织的形态常常不同。LIBR 将术中采集的表面与特征信息结合生物力学模型,用于估计组织形变,并更新内部靶点的空间位置。不同实验条件下的研究结果需分别解读。Preoperative scans and intraoperative tissue often have different shapes. LIBR combines acquired surfaces and features with biomechanical modeling to estimate deformation and update internal target positions. Findings should be interpreted within each study’s experimental setting.

  • 肝脏活体亚表面误差:10.4mm → 6.1±2.8mm(IEEE TBME 2026 一作)Liver in-vivo subsurface: 10.4mm → 6.1±2.8mm (IEEE TBME 2026, first author)
  • 乳腺活体亚表面误差:10.4mm → 4.2±1.0mmBreast in-vivo subsurface: 10.4mm → 4.2±1.0mm
  • 仿体测试(XFEM + 非线性应变硬化):1.7±0.8mmPhantom tests (XFEM + nonlinear strain hardening): 1.7±0.8mm
DEFORMATION ERROR · IN-VIVO LIVER · BASELINE 10.4 mm LIVER · LIBR 6.1 mm BREAST · BASELINE 10.4 mm BREAST · LIBR 4.2 mm PHANTOM · LIBR+ (XFEM) 1.7 mm
头颈导航 · 研究数据HEAD & NECK · RESEARCH DATA

把阳性切缘更准确地找回术野Relocating positive margins in the surgical bed

论文在面颊与头皮尸体模型中,比较了口头引导、口头引导结合标本查看,以及 AR 引导三种定位方式。研究包含 5 位外科住院医师与专科培训医师。The manuscript compared verbal guidance, verbal guidance with specimen examination, and AR guidance on cheek and scalp cadaveric sites, involving five surgical residents and fellows.

  • AR 引导端到端定位误差:6.19 ± 1.79 mmAR-guided end-to-end localization error: 6.19 ± 1.79 mm
  • 在线融合时间:5.23 ± 0.34 sOnline fusion time: 5.23 ± 0.34 s

尸体模型可行性研究,非患者临床疗效数据。融合时间不包含标本扫描等准备步骤;原型附加手动步骤约需 10 分钟。Cadaveric feasibility evidence, not patient clinical efficacy. Fusion time excludes specimen scanning and preparation; additional manual steps took approximately 10 minutes in the prototype.

查看头颈导航研究详情 ↗Explore the head & neck study ↗
端到端定位误差 · 尸体模型END-TO-END LOCALIZATION ERROR · CADAVERIC

均值 ± 标准差,数值越低误差越小Mean ± SD; lower values indicate smaller errors

口头引导Verbal guidance21.40 ± 3.84 mm
口头引导 + 标本查看Verbal guidance + specimen examination16.09 ± 4.30 mm
AR 引导AR guidance6.19 ± 1.79 mm

研究稿件:Marker-free deformable registration and fusion…Source manuscript: Marker-free deformable registration and fusion…

平台架构Architecture

三层架构Three-Layer Architecture

L1
感知层 · Perception Perception Layer RGB-D · AHAT · 光学追踪 · 超声 · 协作臂主动视觉RGB-D · AHAT · Optical Tracking · Ultrasound · Cobot Vision
多模态空间感知:RGB-D 深度相机、AHAT 深度感知、光学追踪、术中超声、协作机械臂主动视觉。Multi-modal spatial sensing: RGB-D depth, AHAT, optical tracking, intraoperative ultrasound, and active vision from cobots.
L2
计算层 · Cognition Cognition Layer LIBR / LIBR+ · 生物力学 · 实时重建 · 语义分割LIBR / LIBR+ · Biomechanics · Real-time Recon · Semantic Segmentation
Spatial AI 核心算法:LIBR / LIBR+ 软组织变形补偿、生物力学建模、实时三维重建、组织语义分割。Spatial AI core: LIBR / LIBR+ deformation correction, biomechanical modeling, real-time 3D reconstruction, tissue semantic segmentation.
L3
协作层 · Co-Pilot Co-Pilot Layer HoloLens / Vision Pro · 手势语音 · 机械臂避障 · Virtual IFSHHoloLens / Vision Pro · Voice & Gesture · Obstacle Avoidance · Virtual IFSH
医生交互与决策:HoloLens / Vision Pro AR 显示、语音手势免手控制、机械臂主动避障、Virtual IFSH 实时虚拟病理。Surgeon interaction & decision: HoloLens / Vision Pro AR display, voice & gesture control, active obstacle avoidance, Virtual IFSH real-time pathology.
导航工作流程Navigation workflow

从 DICOM 到术中决策From DICOM to intraoperative decision

01 / IMAGING

影像建模Imaging & modeling

从 CT、MRI 等影像建立器官、肿瘤和血管的三维模型。Build 3D organ, tumor and vessel models from CT, MRI and other imaging.

02 / SENSING

术中采集Intraoperative sensing

获取当前组织表面与特征,建立术野的空间参考。Capture current tissue surfaces and features to establish a spatial reference.

03 / REGISTRATION

配准与形变Registration & deformation

结合测量与模型,将术前解剖对应到当前组织形态。Combine measurements and modeling to relate preoperative anatomy to current tissue geometry.

04 / VISUALIZATION

术野可视化In-field visualization

以混合现实展示空间关系,支持医生理解靶点与周围结构。Display spatial relationships in mixed reality to contextualize targets and surrounding structures.

影像 → 感知 → 配准 → 显示 · 具体采集方式与算法随导航系统而异IMAGING → SENSING → REGISTRATION → DISPLAY · Acquisition and algorithms vary by navigation system.

知识产权Intellectual Property

"中美双国 + 校内储备"组合"US + China + University reserve" portfolio

CN 202510971966.8
一种混合现实手术导航方法及系统A Mixed Reality Surgical Navigation Method and System
中国发明专利 · 已公布(2025/10/31, 41 卷 4402 期)China Invention Patent · Published 2025/10/31 (Vol 41, Issue 4402)
中国CN
US 63/981,960
Self-Contained Surgical Navigation System in AR HMDSelf-Contained Surgical Navigation System in AR HMD
美国临时专利 · VU25032P2 · 范德堡 2026/02 申请 · 转让/许可通道已建立US Provisional · VU25032P2 · Filed by Vanderbilt 2026/02 · License pathway established
美国US
US 10426556
Biomechanical Model Assisted Image-Guided Surgery SystemBiomechanical Model Assisted Image-Guided Surgery System
美国专利 · 已授权(Miga, Meszoely et al., 2019)US Patent · Granted (Miga, Meszoely et al., 2019)
已授权Granted
VU20125
Computer Vision Apparatus for Breast Surgery Guidance
发明披露(Richey, Heiselman, Miga, 2020)Invention Disclosure (Richey, Heiselman, Miga, 2020)
DISCLOSURE
VU24058
Robotic-Enabled Surgical Navigation Assistant (ReSNA)
发明披露(Miga, Meszoely, 2023)Invention Disclosure (Miga, Meszoely, 2023)
DISCLOSURE
J Med Imaging 12(5):055001
Comprehensive Mixed Reality Surgical Navigation System for Liver Surgery
SCI 期刊 · 2025 · Bowen Xiang 通讯/第一作者SCI Journal · 2025 · Bowen Xiang corresponding/first author
SCI
IEEE TBME 2026
Mixed Reality Surgical Navigation System for Liver Interventions with Comprehensive Validation using Subsurface Target Localization
IEEE TBME · 2026 · Bowen Xiang 第一作者 · DOI 10.1109/TBME.2026.3704934IEEE TBME · 2026 · Bowen Xiang first author · DOI 10.1109/TBME.2026.3704934
SCI
IEEE RA-L 2026
ReSNA: A Robotic-Enabled Surgical Navigation Assistant for Breast-Conserving Surgery
IEEE Robotics and Automation Letters · 2026 · Liu, Xiang, Heiselman, Wu, Meszoely, Miga · DOI 10.1109/LRA.2026.3710046IEEE Robotics and Automation Letters · 2026 · Liu, Xiang, Heiselman, Wu, Meszoely, Miga · DOI 10.1109/LRA.2026.3710046
SCI

与我们一起把 Spatial AI 带入手术室Bring Spatial AI into every OR with us

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